Publications

1. Complex activities of the human Bloom’s syndrome helicase are encoded in a core region comprising the RecA and Zn-binding domains.

Gyimesi M, Harami GM, Sarlós K, Hazai E, Bikádi Z, Kovács M.

Nucleic Acids Res. 2012 Jan 16.

PMID:: 22253018

Free Article

2. Disordered proteins and network disorder in network descriptions of protein structure, dynamics and function. Hypotheses and a comprehensive review.

Csermely P, Sandhu KS, Hazai E, Hoksza Z, Kiss HJ, Veres DV, Piazza F, Nussinov R.

Curr Protein Pept Sci. 2011 Oct 25.

PMID:: 22044146

3. Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein.

Bikadi Z, Hazai I, Malik D, Jemnitz K, Veres Z, Hari P, Ni Z, Loo TW, Clarke DM, Hazai E, Mao Q.

PLoS One. 2011; 6(10):e25815. Epub 2011 Oct 4.

PMID:: 21991360

4. Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity.

Ni Z, Bikadi Z, Shuster DL, Zhao C, Rosenberg MF, Mao Q.

Biochemistry. 2011 Sep 20; 50(37):8057-66. Epub 2011 Aug 26.

PMID:: 21854076

5. pH-Dependent transport of pemetrexed by breast cancer resistance protein.

Li L, Sham YY, Bikadi Z, Elmquist WF.

Drug Metab Dispos. 2011 Sep; 39(9):1478-85. Epub 2011 May 31.

PMID:: 21628496

6. Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking.

Zsila F, Bikadi Z, Malik D, Hari P, Pechan I, Berces A, Hazai E.

Bioinformatics. 2011 Jul 1; 27(13):1806-13. Epub 2011 May 18.

PMID:: 21593135

7. Identification of a polyoxometalate inhibitor of the DNA binding activity of Sox2.

Narasimhan K, Pillay S, Bin Ahmad NR, Bikadi Z, Hazai E, Yan L, Kolatkar PR, Pervushin K, Jauch R.

ACS Chem Biol. 2011 Jun 17; 6(6):573-81. Epub 2011 Mar 7.

PMID:: 21344919

8. Drug transport by breast cancer resistance protein.

Poguntke M, Hazai E, Fromm MF, Zolk O.

Expert Opin Drug Metab Toxicol. 2010 Nov; 6(11):1363-84. Epub 2010 Sep 27.

PMID:: 20873966

9. Structure and function of the human breast cancer resistance protein (BCRP/ABCG2).

Ni Z, Bikadi Z, Rosenberg MF, Mao Q.

Curr Drug Metab. 2010 Sep; 11(7):603-17. Review.

PMID:: 20812902

10. Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport.

Ni Z, Bikadi Z, Cai X, Rosenberg MF, Mao Q.

Am J Physiol Cell Physiol. 2010 Nov; 299(5):C1100-9. Epub 2010 Aug 25.

PMID:: 20739628

11. Functional adaptation of the switch-2 nucleotide sensor enables rapid processive translocation by myosin-5.

Nagy NT, Sakamoto T, Takács B, Gyimesi M, Hazai E, Bikádi Z, Sellers JR, Kovács M.

FASEB J. 2010 Nov; 24(11):4480-90. Epub 2010 Jul 14.

PMID:: 20631329

12. Cyclodextrin KnowledgeBase a web-based service managing CD-ligand complexation data.

Hazai E, Hazai I, Demko L, Kovacs S, Malik D, Akli P, Hari P, Szeman J, Fenyvesi E, Benes E, Szente L, Bikadi Z.

J Comput Aided Mol Des. 2010 Aug; 24(8):713-7. Epub 2010 Jun 3.

PMID:: 20521083

13. The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone.

Rosenberg MF, Bikadi Z, Chan J, Liu X, Ni Z, Cai X, Ford RC, Mao Q.

Structure. 2010 Mar 14; 18(4):482-93. Erratum in: Structure. 2010 Dec 8; 18(12):1688-9.

PMID:: 20399185

14. Structure and stereochemistry of novel ecdysteroids from the roots of Serratula wolffii.

Takács M, Simon A, Liktor-Busa E, Báthori M, Zsila F, Bikádi Z, Horváth P, Veress G, Gergely A, Tóth G.

Magn Reson Chem. 2010 May; 48(5):386-91.

PMID:: 20205207

15. Role of basic residues within or near the predicted transmembrane helix 2 of the human breast cancer resistance protein in drug transport.

Cai X, Bikadi Z, Ni Z, Lee EW, Wang H, Rosenberg MF, Mao Q.

J Pharmacol Exp Ther. 2010 Jun; 333(3):670-81. Epub 2010 Mar 4.

PMID:: 20203106

16. Application of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDock.

Bikadi Z, Hazai E.

J Cheminform. 2009 Sep 11; 1:15.

PMID:: 20150996; [PubMed]

17. A comprehensive study on the 5-hydroxytryptamine(3A) receptor binding of agonists serotonin and m-chlorophenylbiguanidine.

Hazai E, Joshi P, Skoviak EC, Suryanarayanan A, Schulte MK, Bikadi Z.

Bioorg Med Chem. 2009 Aug 15; 17(16):5796-805. Epub 2009 Jul 16.

PMID:: 19640719

18. [DockingServer: molecular docking calculations online].

Hazai E, Kovács S, Demkó L, Bikádi Z.

Acta Pharm Hung. 2009; 79(1):17-21. Hungarian.

PMID:: 19526678

19. In silico description of differential enantioselectivity in methoxychlor O-demethylation by CYP2C enzymes.

Bikádi Z, Hazai E.

Biochim Biophys Acta. 2008 Sep; 1780(9):1070-9. Epub 2008 Jun 9.

PMID:: 18585438

20. Organogold complexes probe a large beta-barrel cavity for human serum alpha1-acid glycoprotein.

Zsila F, Bikádi Z, Hazai E, Simon A, Fitos I, Mády G.

Biochim Biophys Acta. 2008 Jul-Aug; 1784(7-8):1106-14. Epub 2008 Apr 15.

PMID:: 18456008

21. Homology modeling of breast cancer resistance protein (ABCG2).

Hazai E, Bikádi Z.

J Struct Biol. 2008 Apr; 162(1):63-74. Epub 2007 Dec 15.

PMID:: 18249138

22. Cyclodextrin complexes: chiral recognition and complexation behaviour.

Bikádi Z, Iványi R, Szente L, Ilisz I, Hazai E.

Curr Drug Discov Technol. 2007 Dec; 4(4):282-94.

PMID:: 18045090

23. Functional and structural characterization of a protein based on analysis of its hydrogen bonding network by hydrogen bonding plot.

Bikadi Z, Demko L, Hazai E.

Arch Biochem Biophys. 2007 May 15; 461(2):225-34. Epub 2007 Mar 12.

PMID:: 17391641

24. Aggregation of cyclodextrins as an important factor to determine their complexation behavior.

Bikádi Z, Kurdi R, Balogh S, Szemán J, Hazai E.

Chem Biodivers. 2006 Nov; 3(11):1266-78.

PMID:: 17193241

25. Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase.

Hazai E, Bikádi Z, Zsila F, Lockwood SF.

Bioorg Med Chem. 2006 Oct 15; 14(20):6859-67. Epub 2006 Jul 11.

PMID:: 16837203

26. Multiple ligand-binding properties of the lipocalin member chicken alpha1-acid glycoprotein studied by circular dichroism and electronic absorption spectroscopy: the essential role of the conserved tryptophan residue.

Zsila F, Matsunaga H, Bikádi Z, Haginaka J.

Biochim Biophys Acta. 2006 Aug; 1760(8):1248-73. Epub 2006 May 9.

PMID:: 16813999

27. Molecular modeling of non-covalent binding of homochiral (3S, 3′S)-astaxanthin to matrix metalloproteinase-13 (MMP-13).

Bikádi Z, Hazai E, Zsila F, Lockwood SF.

Bioorg Med Chem. 2006 Aug 15; 14(16):5451-8. Epub 2006 May 23.

PMID:: 16716595

28. Probing protein binding sites by circular dichroism spectroscopy.

Zsila F, Bikádi Z, Fitos I, Simonyi M.

Curr Drug Discov Technol. 2004 Jun; 1(2):133-53. Review.

PMID:: 16472252

29. The effects of oral Cardax (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo.

Lockwood SF, Penn MS, Hazen SL, Bikádi Z, Zsila F.

Life Sci. 2006 Jun 6; 79(2):162-74. Epub 2006 Feb 8.

PMID:: 16466747

30. Interactions of granisetron with an agonist-free 5-HT3A receptor model.

Joshi PR, Suryanarayanan A, Hazai E, Schulte MK, Maksay G, Bikádi Z.

Biochemistry. 2006 Jan 31; 45(4):1099-105.

PMID:: 16430206

31. Binding of the pepper alkaloid piperine to bovine beta-lactoglobulin: circular dichroism spectroscopy and molecular modeling study.

Zsila F, Hazai E, Sawyer L.

J Agric Food Chem. 2005 Dec 28; 53(26):10179-85.

PMID:: 16366712

32. Selective binding of coumarin enantiomers to human alpha1-acid glycoprotein genetic variants.

Hazai E, Visy J, Fitos I, Bikádi Z, Simonyi M.

Bioorg Med Chem. 2006 Mar 15; 14(6):1959-65. Epub 2005 Nov 15.

PMID:: 16290938

33. Association of cytochrome P450 enzymes is a determining factor in their catalytic activity.

Hazai E, Bikádi Z, Simonyi M, Kupfer D.

J Comput Aided Mol Des. 2005 Apr; 19(4):271-85.

PMID:: 16163453

34. In vitro binding of leukotriene B4 (LTB4) to human serum albumin: evidence from spectroscopic, molecular modeling, and competitive displacement studies.

Zsila F, Bikádi Z, Lockwood SF.

Bioorg Med Chem Lett. 2005 Aug 15; 15(16):3725-31.

PMID:: 15993588

35. The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide.

Suryanarayanan A, Joshi PR, Bikádi Z, Mani M, Kulkarni TR, Gaines C, Schulte MK.

Biochemistry. 2005 Jun 28; 44(25):9140-9.

PMID:: 15966738

36. Role of CYP2E1 in deramciclane metabolism.

Monostory K, Köhalmy K, Hazai E, Vereczkey L, Kóbori L.

Drug Metab Dispos. 2005 Nov; 33(11):1717-22. Epub 2005 Jun 2.

PMID:: 15932955

Free Article

37. trans-Parinaric acid as a versatile spectroscopic label to study ligand binding properties of bovine beta-lactoglobulin.

Zsila F, Bikádi Z.

Spectrochim Acta A Mol Biomol Spectrosc. 2005 Nov; 62(1-3):666-72.

PMID:: 15893954

38. Optically active oligomer units in aggregates of a highly unsaturated, optically inactive carotenoid phospholipid.

Foss BJ, Sliwka HR, Partali V, Köpsel C, Mayer B, Martin HD, Zsila F, Bikadi Z, Simonyi M.

Chemistry. 2005 Jul 4; 11(14):4103-8.

PMID:: 15861483

39. Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists.

Maksay G, Simonyi M, Bikádi Z.

J Comput Aided Mol Des. 2004 Oct; 18(10):651-64.

PMID:: 15849995

40. Interactions between CYP2C9 and CYP2C19 in reconstituted binary systems influence their catalytic activity: possible rationale for the inability of CYP2C19 to catalyze methoxychlor demethylation in human liver microsomes.

Hazai E, Kupfer D.

Drug Metab Dispos. 2005 Jan; 33(1):157-64. Epub 2004 Oct 14.

PMID:: 15486075

Free Article

41. Circular dichroism spectroscopic studies reveal pH dependent binding of curcumin in the minor groove of natural and synthetic nucleic acids.

Zsila F, Bikadi Z, Simonyi M.

Org Biomol Chem. 2004 Oct 21; 2(20):2902-10. Epub 2004 Sep 23.

PMID:: 15480453

Free Article

42. In vitro plasma protein binding and aqueous aggregation behavior of astaxanthin dilysinate tetrahydrochloride.

Zsila F, Fitos I, Bikádi Z, Simonyi M, Jackson HL, Lockwood SF.

Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5357-66.

PMID:: 15454227

43. Glucuronidation of the oxidative cytochrome P450-mediated phenolic metabolites of the endocrine disruptor pesticide: methoxychlor by human hepatic UDP-glucuronosyl transferases.

Hazai E, Gagne PV, Kupfer D.

Drug Metab Dispos. 2004 Jul; 32(7):742-51. Erratum in: Drug Metab Dispos. 2004 Sep; 32(9):1055.

PMID:: 15205390

Free Article

44. Induced circular dichroism spectra reveal binding of the antiinflammatory curcumin to human alpha1-acid glycoprotein.

Zsila F, Bikádi Z, Simonyi M.

Bioorg Med Chem. 2004 Jun 15; 12(12):3239-45.

PMID:: 15158792

45. Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors.

Monostory K, Hazai E, Vereczkey L.

Chem Biol Interact. 2004 Apr 15; 147(3):331-40.

PMID:: 15135088

46. Specific ligand binding on genetic variants of human alpha1-acid glycoprotein studied by circular dichroism spectroscopy.

Fitos I, Visy J, Zsila F, Bikádi Z, Mády G, Simonyi M.

Biochem Pharmacol. 2004 Feb 15; 67(4):679-88.

PMID:: 14757167

47. Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models.

Maksay G, Bikádi Z, Simonyi M.

J Recept Signal Transduct Res. 2003; 23(2-3):255-70.

PMID:: 14626451

48. GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer.

Tamási V, Hazai E, Porsmyr-Palmertz M, Ingelman-Sundberg M, Vereczkey L, Monostory K.

Drug Metab Dispos. 2003 Nov; 31(11):1310-4.

PMID:: 14570761

Free Article

49. Muscarinic and nicotinic cholinergic agonists: structural analogies and discrepancies.

Bikádi Z, Simonyi M.

Curr Med Chem. 2003 Dec; 10(23):2611-20. Review.

PMID:: 14529475

50. Supramolecular exciton chirality of carotenoid aggregates.

Simonyi M, Bikádi Z, Zsila F, Deli J.

Chirality. 2003 Oct; 15(8):680-98. Review.

PMID:: 12923806

51. Unique, pH-dependent biphasic band shape of the visible circular dichroism of curcumin-serum albumin complex.

Zsila F, Bikádi Z, Simonyi M.

Biochem Biophys Res Commun. 2003 Feb 14; 301(3):776-82.

PMID:: 12565848

52. Probing the binding of the flavonoid, quercetin to human serum albumin by circular dichroism, electronic absorption spectroscopy and molecular modelling methods.

Zsila F, Bikádi Z, Simonyi M.

Biochem Pharmacol. 2003 Feb 1; 65(3):447-56.

PMID:: 12527338

53. Retinoic acid binding properties of the lipocalin member beta-lactoglobulin studied by circular dichroism, electronic absorption spectroscopy and molecular modeling methods.

Zsila F, Bikádi Z, Simonyi M.

Biochem Pharmacol. 2002 Dec 1; 64(11):1651-60.

PMID:: 12429354

54. The supramolecular structure of self-assembly formed by capsanthin derivatives.

Bikádi Z, Zsila F, Deli J, Mády G, Simonyi M.

Enantiomer. 2002 Mar-Jun; 7(2-3):67-76.

PMID:: 12108636

55. Induced chirality upon binding of cis-parinaric acid to bovine beta-lactoglobulin: spectroscopic characterization of the complex.

Zsila F, Imre T, Szabó PT, Bikádi Z, Simonyi M.

FEBS Lett. 2002 Jun 5; 520(1-3):81-7.

PMID:: 12044875

56. Reduction of toxic metabolite formation of acetaminophen.

Hazai E, Vereczkey L, Monostory K.

Biochem Biophys Res Commun. 2002 Mar 8; 291(4):1089-94.

PMID:: 11866476

57. Supramolecular assemblies of carotenoids.

Zsila F, Deli J, Bikádi Z, Simonyi M.

Chirality. 2001; 13(10):739-44.

PMID:: 11746813

58. Chiral detection of carotenoid assemblies.

Zsila F, Bikádi Z, Deli J, Simonyi M.

Chirality. 2001 Aug; 13(8):446-53.

PMID:: 11466767

59. [About paracetamol again].

Hazai E, Monostory K, Bakos A, Zacher G, Vereczkey L.

Orv Hetil. 2001 Feb 18; 142(7):345-9. Review. Hungarian.

PMID:: 11243017

60. [Human drug metabolizing enzymes III. Epoxide hydrolases, esterases, and amidases].

Hazai E, Róna K, Vereczkey L.

Acta Pharm Hung. 1999 Sep; 69(4):208-12. Review. Hungarian.

PMID:: 10544521