Publications
1. Transmembrane Helices 1 and 6 of the Human Breast Cancer Resistance Protein (BCRP/ABCG2): Identification of Polar Residues Important for Drug Transport.Ni Z, Bikadi Z, Cai X, Rosenberg MF, Mao Q.Am J Physiol Cell Physiol. 2010 Aug 25. PMID: 20739628
2. Functional adaptation of the switch-2 nucleotide sensor enables rapid processive translocation by myosin-5.Nagy NT, Sakamoto T, Takács B, Gyimesi M, Hazai E, Bikádi Z, Sellers JR, Kovács M.FASEB J. 2010 Jul 14. PMID: 20631329
3. Cyclodextrin KnowledgeBase a web-based service managing CD-ligand complexation data. Hazai E, Hazai I, Demko L, Kovacs S, Malik D, Akli P, Hari P, Szeman J, Fenyvesi E, Benes E, Szente L, Bikadi Z. J Comput Aided Mol Des. 2010 Aug; 24(8):713-7. Epub 2010 Jun 3.PMID: 20521083
4. The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone.Rosenberg MF, Bikadi Z, Chan J, Liu X, Ni Z, Cai X, Ford RC, Mao Q.Structure. 2010 Mar 14; 18(4):482-93.PMID: 20399185 Free text
5. Structure and stereochemistry of novel ecdysteroids from the roots of Serratula wolffii.Takács M, Simon A, Liktor-Busa E, Báthori M, Zsila F, Bikádi Z, Horváth P, Veress G, Gergely A, Tóth G.Magn Reson Chem. 2010 May; 48(5):386-91.PMID: 20205207
6. Role of basic residues within or near the predicted transmembrane helix 2 of the human breast cancer resistance protein in drug transport.Cai X, Bikadi Z, Ni Z, Lee EW, Wang H, Rosenberg MF, Mao Q.J Pharmacol Exp Ther. 2010 Jun; 333(3):670-81. Epub 2010 Mar 4.PMID: 20203106
7. Application of the PM6 semi-empirical method to modeling proteins enhances docking accuracy of AutoDock. Bikadi Z, Hazai E. J Cheminform. 2009 Sep 11; 1:15.PMID: 20150996 Free text
8. A comprehensive study on the 5-hydroxytryptamine(3A) receptor binding of agonists serotonin and m-chlorophenylbiguanidine. Hazai E, Joshi P, Skoviak EC, Suryanarayanan A, Schulte MK, Bikadi Z. Bioorg Med Chem. 2009 Aug 15; 17(16):5796-805. Epub 2009 Jul 16.PMID: 19640719
9. [DockingServer: molecular docking calculations online] Hazai E, Kovács S, Demkó L, Bikádi Z. Acta Pharm Hung. 2009; 79(1):17-21. Hungarian. PMID: 19526678
10. In silico description of differential enantioselectivity in methoxychlor O-demethylation by CYP2C enzymes. Bikádi Z, Hazai E. Biochim Biophys Acta. 2008 Sep; 1780(9):1070-9. Epub 2008 Jun 9.PMID: 18585438
11. Organogold complexes probe a large beta-barrel cavity for human serum alpha1-acid glycoprotein. Zsila F, Bikádi Z, Hazai E, Simon A, Fitos I, Mády G.Biochim Biophys Acta. 2008 Jul-Aug; 1784(7-8):1106-14. Epub 2008 Apr 15.PMID: 18456008
12. Homology modeling of breast cancer resistance protein (ABCG2). Hazai E, Bikádi Z. J Struct Biol. 2008 Apr; 162(1):63-74. Epub 2007 Dec 15.PMID: 18249138
13. Cyclodextrin complexes: chiral recognition and complexation behaviour. Bikádi Z, Iványi R, Szente L, Ilisz I, Hazai E. Curr Drug Discov Technol. 2007 Dec; 4(4):282-94.PMID: 18045090
14. Functional and structural characterization of a protein based on analysis of its hydrogen bonding network by hydrogen bonding plot. Bikadi Z, Demko L, Hazai E. Arch Biochem Biophys. 2007 May 15; 461(2):225-34. Epub 2007 Mar 12.PMID: 17391641
15. Aggregation of cyclodextrins as an important factor to determine their complexation behavior. Bikádi Z, Kurdi R, Balogh S, Szemán J, Hazai E. Chem Biodivers. 2006 Nov; 3(11):1266-78.PMID: 17193241
16. Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase. Hazai E, Bikádi Z, Zsila F, Lockwood SF.Bioorg Med Chem. 2006 Oct 15; 14(20):6859-67. Epub 2006 Jul 11.PMID: 16837203
17. Multiple ligand-binding properties of the lipocalin member chicken alpha1-acid glycoprotein studied by circular dichroism and electronic absorption spectroscopy: the essential role of the conserved tryptophan residue. Zsila F, Matsunaga H, Bikádi Z, Haginaka J.Biochim Biophys Acta. 2006 Aug; 1760(8):1248-73. Epub 2006 May 9.PMID: 16813999
18. Molecular modeling of non-covalent binding of homochiral (3S, 3′S)-astaxanthin to matrix metalloproteinase-13 (MMP-13). Bikádi Z, Hazai E, Zsila F, Lockwood SF.Bioorg Med Chem. 2006 Aug 15; 14(16):5451-8. Epub 2006 May 23.PMID: 16716595
19. Probing protein binding sites by circular dichroism spectroscopy. Zsila F, Bikádi Z, Fitos I, Simonyi M. Curr Drug Discov Technol. 2004 Jun; 1(2):133-53. Review.PMID: 16472252
20. The effects of oral Cardax (disodium disuccinate astaxanthin) on multiple independent oxidative stress markers in a mouse peritoneal inflammation model: influence on 5-lipoxygenase in vitro and in vivo.Lockwood SF, Penn MS, Hazen SL, Bikádi Z, Zsila F.Life Sci. 2006 Jun 6; 79(2):162-74. Epub 2006 Feb 8.PMID: 16466747
21. Interactions of granisetron with an agonist-free 5-HT3A receptor model.Joshi PR, Suryanarayanan A, Hazai E, Schulte MK, Maksay G, Bikádi Z. Biochemistry. 2006 Jan 31; 45(4):1099-105.PMID: 16430206
22. Binding of the pepper alkaloid piperine to bovine beta-lactoglobulin: circular dichroism spectroscopy and molecular modeling study. Zsila F, Hazai E, Sawyer L.J Agric Food Chem. 2005 Dec 28; 53(26):10179-85.PMID: 16366712
23. Selective binding of coumarin enantiomers to human alpha1-acid glycoprotein genetic variants. Hazai E, Visy J, Fitos I, Bikádi Z, Simonyi M. Bioorg Med Chem. 2006 Mar 15; 14(6):1959-65. Epub 2005 Nov 15.PMID: 16290938
24. Association of cytochrome P450 enzymes is a determining factor in their catalytic activity. Hazai E, Bikádi Z, Simonyi M, Kupfer D.J Comput Aided Mol Des. 2005 Apr; 19(4):271-85.PMID: 16163453
25. In vitro binding of leukotriene B4 (LTB4) to human serum albumin: evidence from spectroscopic, molecular modeling, and competitive displacement studies. Zsila F, Bikádi Z, Lockwood SF.Bioorg Med Chem Lett. 2005 Aug 15; 15(16):3725-31.PMID: 15993588
26. The loop C region of the murine 5-HT3A receptor contributes to the differential actions of 5-hydroxytryptamine and m-chlorophenylbiguanide.Suryanarayanan A, Joshi PR, Bikádi Z, Mani M, Kulkarni TR, Gaines C, Schulte MK.Biochemistry. 2005 Jun 28; 44(25):9140-9.PMID: 15966738
27. Role of CYP2E1 in deramciclane metabolism.Monostory K, Köhalmy K, Hazai E, Vereczkey L, Kóbori L.Drug Metab Dispos. 2005 Nov; 33(11):1717-22. Epub 2005 Jun 2.PMID: 15932955 Free Article
28. trans-Parinaric acid as a versatile spectroscopic label to study ligand binding properties of bovine beta-lactoglobulin. Zsila F, Bikádi Z. Spectrochim Acta A Mol Biomol Spectrosc. 2005 Nov; 62(1-3):666-72.PMID: 15893954
29. Optically active oligomer units in aggregates of a highly unsaturated, optically inactive carotenoid phospholipid.Foss BJ, Sliwka HR, Partali V, Köpsel C, Mayer B, Martin HD, Zsila F, Bikadi Z, Simonyi M. Chemistry. 2005 Jul 4; 11(14):4103-8.PMID: 15861483
30. Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists.Maksay G, Simonyi M, Bikádi Z. J Comput Aided Mol Des. 2004 Oct; 18(10):651-64.PMID: 15849995
31. Interactions between CYP2C9 and CYP2C19 in reconstituted binary systems influence their catalytic activity: possible rationale for the inability of CYP2C19 to catalyze methoxychlor demethylation in human liver microsomes. Hazai E, Kupfer D.Drug Metab Dispos. 2005 Jan; 33(1):157-64. Epub 2004 Oct 14.PMID: 15486075 Free Article
32. Circular dichroism spectroscopic studies reveal pH dependent binding of curcumin in the minor groove of natural and synthetic nucleic acids. Zsila F, Bikadi Z, Simonyi M. Org Biomol Chem. 2004 Oct 21; 2(20):2902-10. Epub 2004 Sep 23.PMID: 15480453 Free Article
33. In vitro plasma protein binding and aqueous aggregation behavior of astaxanthin dilysinate tetrahydrochloride. Zsila F, Fitos I, Bikádi Z, Simonyi M, Jackson HL, Lockwood SF.Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5357-66.PMID: 15454227
34. Glucuronidation of the oxidative cytochrome P450-mediated phenolic metabolites of the endocrine disruptor pesticide: methoxychlor by human hepatic UDP-glucuronosyl transferases. Hazai E, Gagne PV, Kupfer D.Drug Metab Dispos. 2004 Jul; 32(7):742-51. Erratum in: Drug Metab Dispos. 2004 Sep; 32(9):1055. PMID: 15205390 Free Article
35. Induced circular dichroism spectra reveal binding of the antiinflammatory curcumin to human alpha1-acid glycoprotein. Zsila F, Bikádi Z, Simonyi M. Bioorg Med Chem. 2004 Jun 15; 12(12):3239-45.PMID: 15158792
36. Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors.Monostory K, Hazai E, Vereczkey L.Chem Biol Interact. 2004 Apr 15; 147(3):331-40.PMID: 15135088
37. Specific ligand binding on genetic variants of human alpha1-acid glycoprotein studied by circular dichroism spectroscopy.Fitos I, Visy J, Zsila F, Bikádi Z, Mády G, Simonyi M. Biochem Pharmacol. 2004 Feb 15; 67(4):679-88.PMID: 14757167
38. Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models.Maksay G, Bikádi Z, Simonyi M. J Recept Signal Transduct Res. 2003; 23(2-3):255-70.PMID: 14626451
39. GYKI-47261, a new AMPA [2-amino-3-(3-hydroxymethylisoxazole-4-yl)propionic acid] antagonist, is a CYP2E1 inducer.Tamási V, Hazai E, Porsmyr-Palmertz M, Ingelman-Sundberg M, Vereczkey L, Monostory K.Drug Metab Dispos. 2003 Nov; 31(11):1310-4.PMID: 14570761 Free Article
40. Muscarinic and nicotinic cholinergic agonists: structural analogies and discrepancies. Bikádi Z, Simonyi M. Curr Med Chem. 2003 Dec; 10(23):2611-20. Review.PMID: 14529475
41. Supramolecular exciton chirality of carotenoid aggregates.Simonyi M, Bikádi Z, Zsila F, Deli J.Chirality. 2003 Oct; 15(8):680-98. Review.PMID: 12923806
42. Unique, pH-dependent biphasic band shape of the visible circular dichroism of curcumin-serum albumin complex. Zsila F, Bikádi Z, Simonyi M. Biochem Biophys Res Commun. 2003 Feb 14; 301(3):776-82.PMID: 12565848
43. Probing the binding of the flavonoid, quercetin to human serum albumin by circular dichroism, electronic absorption spectroscopy and molecular modelling methods. Zsila F, Bikádi Z, Simonyi M. Biochem Pharmacol. 2003 Feb 1; 65(3):447-56.PMID: 12527338
44. Retinoic acid binding properties of the lipocalin member beta-lactoglobulin studied by circular dichroism, electronic absorption spectroscopy and molecular modeling methods. Zsila F, Bikádi Z, Simonyi M. Biochem Pharmacol. 2002 Dec 1; 64(11):1651-60.PMID: 12429354
45. The supramolecular structure of self-assembly formed by capsanthin derivatives. Bikádi Z, Zsila F, Deli J, Mády G, Simonyi M. Enantiomer. 2002 Mar-Jun; 7(2-3):67-76.PMID: 12108636
46. Induced chirality upon binding of cis-parinaric acid to bovine beta-lactoglobulin: spectroscopic characterization of the complex. Zsila F, Imre T, Szabó PT, Bikádi Z, Simonyi M. FEBS Lett. 2002 Jun 5; 520(1-3):81-7.PMID: 12044875
47. Reduction of toxic metabolite formation of acetaminophen. Hazai E, Vereczkey L, Monostory K.Biochem Biophys Res Commun. 2002 Mar 8; 291(4):1089-94.PMID: 11866476
48. Supramolecular assemblies of carotenoids. Zsila F, Deli J, Bikádi Z, Simonyi M. Chirality. 2001; 13(10):739-44.PMID: 11746813
49. Chiral detection of carotenoid assemblies. Zsila F, Bikádi Z, Deli J, Simonyi M. Chirality. 2001 Aug; 13(8):446-53.PMID: 11466767
50. [About paracetamol again] Hazai E, Monostory K, Bakos A, Zacher G, Vereczkey L.Orv Hetil. 2001 Feb 18; 142(7):345-9. Review. Hungarian. PMID: 11243017
51. [Human drug metabolizing enzymes III. Epoxide hydrolases, esterases, and amidases] Hazai E, Róna K, Vereczkey L.Acta Pharm Hung. 1999 Sep; 69(4):208-12. Review. Hungarian. PMID: 10544521